Adriamycin-resistant cells are significantly less fit than adriamycin-sensitive cells in cervical cancer
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چکیده
منابع مشابه
Collateral sensitivity to methotrexate in cells resistant to adriamycin.
Chinese hamster ovary (CHO) cells, maintained and treated in log-phase growth, are extremely sensitive to Adniamycin but are very resistant to methotrexate-induced cell killing. The survival response to Adniamycin is biphasic, with the sensitive population showing a D0 of 0.08 pg/mI for 1 hr, while essen tially no cell killing is produced by methotrexate treatments of up to 500 @.tg/mI for eith...
متن کاملHyperthermia, adriamycin transport, and cytotoxicity in drug-sensitive and -resistant Chinese hamster ovary cells.
Adriamycin cytotoxicity and membrane permeability to Adriamycin were studied at elevated temperatures in a drug-sensitive Chinese hamster ovary cell line and in a pleiotropic drug-resistant mutant to determine whether hyperthermia can overcome this form of acquired drug resistance. In drug-sensitive cells Adriamycin cytotoxicity, measured by colony survival studies, increased at temperatures as...
متن کامل[Effect of verapamil on adriamycin resistant bladder tumor cells].
RBT-K5 cell line was established from a male Wistar rat bladder tumor induced with N-butyl-N-(4-hydroxybutyl) nitrosamine. RBT-K5 (ADM res.) cell line, adriamycin (ADM) resistant, was also established from RBT-K5 cells by stepwise escalation of ADM concentrations in vitro. In this study, we have examined the effect of verapamil (VR) on intracellular ADM concentration in these cell lines. The vi...
متن کاملDifferential oxygen radical susceptibility of adriamycin-sensitive and -resistant MCF-7 human breast tumor cells.
Recent evidence supports the concept that Adriamycin cytotoxicity may be mediated by drug semiquinone free radical and oxyradical generation. We tested this hypothesis further by exposing drug-sensitive (WT) and 500-fold Adriamycin-resistant MCF-7 human breast tumor cells (ADRR) to exogenous superoxide- and hydrogen peroxide-generating systems and subsequently monitored cell proliferation as a ...
متن کاملRole of FoxO1 activation in MDR1 expression in adriamycin-resistant breast cancer cells.
The development of multidrug resistance 1 (MDR1) can be mediated by a number of different mechanisms but elevated gene expression of MDR1 (P-glycoprotein) has often been a major cause of chemoresistance in many cancer cells. Therefore, the present study aimed to investigate the role of forkhead box-containing protein, O subfamily (FoxO), transcription factors in regulating the MDR1 gene express...
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ژورنال
عنوان ژورنال: Open Life Sciences
سال: 2021
ISSN: 2391-5412
DOI: 10.1515/biol-2021-0004